KYP-2047 (Standard)

KYP-2047 (Standard) is the analytical standard of KYP-2047 (HY-100475) . This product is intended for research and analytical applications. KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation[1][2].

Product Specifications

CAS Number

[796874-99-2]

Target

Apoptosis; MDM-2/p53; Prolyl Endopeptidase (PREP) ; Reference Standards

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

N#C[C@H]1N(C([C@H]2N(C(CCCC3=CC=CC=C3)=O)CCC2)=O)CCC1

Molecular Formula

C20H25N3O2

Molecular Weight

339.43

References & Citations

[1]Jalkanen AJ, et al. Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats. Basic Clin Pharmacol Toxicol. 2007 Feb;100 (2) :132-8.|[2]Scuderi SA, et al. KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation. Cancers (Basel) . 2021 Jul 9;13 (14) :3444.