NSC781406 (Standard)

NSC781406 (Standard) is the analytical standard of NSC781406 (HY-100470) . This product is intended for research and analytical applications. NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα.

Product Specifications

CAS Number

[1676893-24-5]

Target

MTOR; PI3K; Reference Standards

Related Pathways

Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

FC1=CC(F)=CC=C1S(=O)(NC2=CC(C3=CC=C(N=CC=C4C#CCN5CCN(S(C)(=O)=O)CC5)C4=C3)=CN=C2OC)=O

Molecular Formula

C29H27F2N5O5S2

Molecular Weight

627.68

References & Citations

[1]Chen Y, et al. Discovery of benzenesulfonamide derivatives as potent PI3K/mTOR dual inhibitors with in vivo efficacies against hepatocellular carcinoma. Bioorg Med Chem. 2016 Mar 1;24 (5) :957-66.