REV7/REV3L-IN-1 (Standard)
REV7/REV3L-IN-1 (Standard) is the analytical standard of REV7/REV3L-IN-1 (HY-100468) . This product is intended for research and analytical applications. REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC50 of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions[1].
Product Specifications
CAS Number
[1979192-13-6]
Target
DNA/RNA Synthesis; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C(C)N1CCC(CN2C=NC(SC=C3C4=CC=C(C)O4)=C3C2=O)CC1
Molecular Formula
C19H21N3O3S
Molecular Weight
371.45
References & Citations
[1]Actis ML, et al. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction. Bioorg Med Chem. 2016 Sep 15;24 (18) :4339-4346.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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