IC87201 (Standard)
IC87201 (Standard) is the analytical standard of IC87201. This product is intended for research and analytical applications. IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.
Product Specifications
CAS Number
866927-10-8
Target
IGluR; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
OC1=C(Cl)C=C(Cl)C=C1CNC2=CC=C3N=NNC3=C2
Molecular Formula
C13H10Cl2N4O
Molecular Weight
309.15
References & Citations
[1]Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157.|[2]Smith AE, et al. Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein-protein interaction inhibitors. Behav Brain Res. 2016 May 15;305:23-9.|[3]Doucet MV, et al. Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons. Neuroscience. 2015 Aug 20;301:421-38.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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