TCS-OX2-29 (Standard)

TCS-OX2-29 (Standard) is the analytical standard of TCS-OX2-29 (HY-100452) . This product is intended for research and analytical applications. TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1[1][2].

Product Specifications

CAS Number

[372523-75-6]

Target

Orexin Receptor (OX Receptor) ; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Cancer; Endocrinology

Smiles

CC(C)(C)[C@H](NCC1=CC=NC=C1)C(N2CC3=C(C=C(OC)C(OC)=C3)CC2)=O

Molecular Formula

C23H31N3O3

Molecular Weight

397.51

References & Citations

[1]Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13 (24) :4497-9.|[2]R Mould et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan; 171 (2) : 351-363.