TCS-OX2-29 (Standard)
TCS-OX2-29 (Standard) is the analytical standard of TCS-OX2-29. This product is intended for research and analytical applications. TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1[1][2].
Product Specifications
CAS Number
372523-75-6
Target
Orexin Receptor (OX Receptor) ; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Cancer; Endocrinology
Smiles
CC(C)(C)[C@H](NCC1=CC=NC=C1)C(N2CC3=C(C=C(OC)C(OC)=C3)CC2)=O
Molecular Formula
C23H31N3O3
Molecular Weight
397.51
References & Citations
[1]Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13 (24) :4497-9.|[2]R Mould et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan; 171 (2) : 351-363.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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