WYE-132 (Standard)
WYE-132 (Standard) is the analytical standard of WYE-132. This product is intended for research and analytical applications. WYE-132 (WYE-125132) is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks). WYE-132 (WYE-125132) inhibits mTORC1 and mTORC2.
Product Specifications
CAS Number
1144068-46-1
Target
Apoptosis; mTOR; Reference Standards
Related Pathways
Apoptosis; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(C2=NC(N3CC4CCC(C3)O4)=C5C(N(N=C5)C6CCC7(CC6)OCCO7)=N2)C=C1)NC
Molecular Formula
C27H33N7O4
Molecular Weight
519.60
References & Citations
[1]Yu K, et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.Cancer Res. 2010 Jan 15;70 (2) :621-631.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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