WYE-132 (Standard)

WYE-132 (Standard) is the analytical standard of WYE-132 (HY-10044) . This product is intended for research and analytical applications. WYE-132 (WYE-125132) is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks) . WYE-132 (WYE-125132) inhibits mTORC1 and mTORC2.

Product Specifications

CAS Number

[1144068-46-1]

Target

Apoptosis; mTOR; Reference Standards

Related Pathways

Apoptosis; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C(NC1=CC=C(C2=NC(N3CC4CCC(C3)O4)=C5C(N(N=C5)C6CCC7(CC6)OCCO7)=N2)C=C1)NC

Molecular Formula

C27H33N7O4

Molecular Weight

519.60

References & Citations

[1]Yu K, et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.Cancer Res. 2010 Jan 15;70 (2) :621-631.