Paquinimod (Standard)

Paquinimod (Standard) is the analytical standard of Paquinimod. This product is intended for research and analytical applications. Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice[1][2][3].

Product Specifications

CAS Number

[248282-01-1]

Product Name Alternative

ABR-215757 (Standard) ; ABR 25757 (Standard)

UNSPSC

12352005

Target

Reference Standards; SARS-CoV

Related Pathways

Anti-infection; Others

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

O=C(C1=C(O)C2=C(C=CC=C2CC)N(C)C1=O)N(CC)C3=CC=CC=C3

Molecular Formula

C21H22N2O3

Molecular Weight

350.41

References & Citations

[1]Schelbergen RF, et al. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Ann Rheum Dis. 2015 Dec;74 (12) :2254-8.|[2]Tahvili S, et al. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse. PLoS One. 2018 May 9;13 (5) :e0196598.|[3]Qirui Guo, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe. 2021 Feb 10;29 (2) :222-235.e4.