Hydronidone (Standard)

Hydronidone (Standard) is the analytical standard of Hydronidone (HY-100438) . This product is intended for research and analytical applications. Hydronidone is an orally active pyridine derivative. Hydronidone is an inhibitor of phosphodiesterase-4 (PDE4) and cyclo-oxygenase (COX) as well as TGF-β. Hydronidone induces mitochondrial dysfunction and triggers apoptosis. Hydronidone can be used for liver fibrosis, anti-inflammation and anti-cancer study[1][2][3].

Product Specifications

CAS Number

[851518-71-3]

Target

Apoptosis; COX; Mitochondrial Metabolism; Phosphodiesterase (PDE) ; Reference Standards; TGF-beta/Smad

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C1C=CC(C)=CN1C2=CC=C(O)C=C2

Molecular Formula

C12H11NO2

Molecular Weight

201.22

References & Citations

[1]Xu X, et al. Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFβRI. Liver Int. 2023 Nov;43 (11) :2523-2537.|[2]Sun Z, et al. Hydronidone induces apoptosis in activated hepatic stellate cells through endoplasmic reticulum stress-associated mitochondrial apoptotic pathway. J Gastroenterol Hepatol. 2024 Aug;39 (8) :1695-1703.|[3]Juillerat-Jeanneret L, et al. Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction. J Med Chem. 2018 Nov 21;61 (22) :9811-9840.