IMR-1A (Standard)
IMR-1A (Standard) is the analytical standard of IMR-1A. This product is intended for research and analytical applications. IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1].
Product Specifications
CAS Number
[331862-41-0]
UNSPSC
12352005
Target
Drug Metabolite; Notch; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling; Others; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(O)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC
Molecular Formula
C13H11NO5S2
Molecular Weight
325.36
References & Citations
[1]Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76 (12) :3593-603.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
