IMR-1A (Standard)

IMR-1A (Standard) is the analytical standard of IMR-1A. This product is intended for research and analytical applications. IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1].

Product Specifications

CAS Number

[331862-41-0]

UNSPSC

12352005

Target

Drug Metabolite; Notch; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling; Others; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(O)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC

Molecular Formula

C13H11NO5S2

Molecular Weight

325.36

References & Citations

[1]Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76 (12) :3593-603.