Eltanexor Z-isomer (Standard)

Eltanexor Z-isomer (Standard) is the analytical standard of Eltanexor Z-isomer (HY-100423A) . This product is intended for research and analytical applications. 0

Product Specifications

CAS Number

[1642300-78-4]

Target

CRM1; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Cancer

Smiles

O=C(N)/C(C1=CN=CN=C1)=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2

Molecular Formula

C17H10F6N6O

Molecular Weight

428.29

References & Citations

[1]Vercruysse T et al. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia. Clin Cancer Res. 2016 Oct 25.|[2]Hing ZA et al. Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia. 2016 Jun 21.|[3]Etchin J et al. KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells. Leukemia. 2016 Jun 24.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards