LY2365109 (hydrochloride) (Standard)
LY2365109 (hydrochloride) (Standard) is the analytical standard of LY2365109 (hydrochloride). This product is intended for research and analytical applications. LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a[1][2].
Product Specifications
CAS Number
1779796-27-8
Target
GlyT; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C.Cl[H]
Molecular Formula
C22H28ClNO5
Molecular Weight
421.91
References & Citations
[1]Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55 (5) :743-54.|[2]Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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