JNJ16259685 (Standard)

JNJ16259685 (Standard) is the analytical standard of JNJ16259685 (HY-100407) . This product is intended for research and analytical applications. JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.

Product Specifications

CAS Number

[409345-29-5]

Target

MGluR; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

O=C(C1=CC=C2N=C3C(CCCO3)=CC2=C1)[C@H]4CC[C@@H](OC)CC4

Molecular Formula

C20H23NO3

Molecular Weight

325.40

References & Citations

[1]Navarro JF, et al. JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice. Eur J Pharmacol. 2008 May 31;586 (1-3) :217-20.|[2]Hodgson RA, et al. Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination. Pharmacol Biochem Behav. 2011 Apr;98 (2) :181-7.|[3]Lavreysen H, et al. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology. 2004 Dec;47 (7) :961-72.|[4]I Fukunaga , et al. Potent and Specific Action of the mGlu1 Antagonists YM-298198 and JNJ16259685 on Synaptic Transmission in Rat Cerebellar Slices. Br J Pharmacol. 2007 Jul;151 (6) :870-6.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards