K-604 (dihydrochloride) (Standard)
K-604 (dihydrochloride) (Standard) is the analytical standard of K-604 (dihydrochloride) . This product is intended for research and analytical applications. K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM.
Product Specifications
CAS Number
217094-32-1
UNSPSC
12352005
Target
Acyltransferase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(NC1=C(SC)C=C(C)N=C1SC)CN2CCN(CCSC3=NC4=CC=CC=C4N3)CC2.[H]Cl.[H]Cl
Molecular Formula
C23H32Cl2N6OS3
Molecular Weight
575.64
References & Citations
[1]Ikenoya M, et al. A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 2007 Apr;191 (2) :290-7.|[2]Shibuya Y, et al. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage. Neurobiol Aging. 2015 Jul;36 (7) :2248-2259.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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