SHP099 (Standard)

SHP099 (Standard) is the analytical standard of SHP099. This product is intended for research and analytical applications. SHP099 is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, SHP2E76K. SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 μM) . SHP099 inhibits RAS-ERK signaling and inhibits tumor growth[1][2].

Product Specifications

CAS Number

[1801747-42-1]

UNSPSC

12352005

Target

Phosphatase; Reference Standards; SHP2

Related Pathways

Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

NC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl

Molecular Formula

C16H19Cl2N5

Molecular Weight

352.26

References & Citations

[1]Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535 (7610) :148-52.|[2]Sun X, et al. Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099. Leukemia. 2018 May;32 (5) :1246-1249.