SHP099 (monohydrochloride) (Standard)
SHP099 (monohydrochloride) (Standard) is the analytical standard of SHP099 (monohydrochloride) . This product is intended for research and analytical applications. SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM[1].
Product Specifications
CAS Number
2200214-93-1
UNSPSC
12352005
Target
Phosphatase; Reference Standards; SHP2
Related Pathways
Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
NC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl.Cl
Molecular Formula
C16H20Cl3N5
Molecular Weight
388.72
References & Citations
[1]Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59 (17) :7773-82.|[2]Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535 (7610) :148-52.|[3]Carmine Fedele, et al. SHP2 Inhibition Abrogates MEK inhibitor Resistance in Multiple Cancer Models. bioRxiv. April 25, 2018.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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