SHP099 (monohydrochloride) (Standard)

SHP099 (monohydrochloride) (Standard) is the analytical standard of SHP099 (monohydrochloride) . This product is intended for research and analytical applications. SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM[1].

Product Specifications

CAS Number

[2200214-93-1]

UNSPSC

12352005

Target

Phosphatase; Reference Standards; SHP2

Related Pathways

Metabolic Enzyme/Protease; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

NC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl.Cl

Molecular Formula

C16H20Cl3N5

Molecular Weight

388.72

References & Citations

[1]Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59 (17) :7773-82.|[2]Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535 (7610) :148-52.|[3]Carmine Fedele, et al. SHP2 Inhibition Abrogates MEK inhibitor Resistance in Multiple Cancer Models. bioRxiv. April 25, 2018.