Isavuconazonium (sulfate) (Standard)

Isavuconazonium (sulfate) (Standard) is the analytical standard of Isavuconazonium (sulfate) (HY-100373) . This product is intended for research and analytical applications. Isavuconazonium sulfate (BAL8557-002) is an orally active broad-spectrum antifungal molecule. Isavuconazonium sulfate is a precursor of the triazole antifungal active molecule Isavuconazole. Isavuconazonium sulfate can be used in the study of invasive aspergillosis, mucormycosis, blastomycosis, and Acanthamoeba keratitis[1][2][3][4][5].

Product Specifications

CAS Number

[946075-13-4]

Target

Fungal; Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

O[C@@](CN(N=C1)C=[N+]1C(C)OC(N(C(N=CC=C2)=C2COC(CNC)=O)C)=O)(C(C=C3F)=C(C=C3)F)[C@H](C4=NC(C(C=C5)=CC=C5C#N)=CS4)C.O=[S]([O-])(O)=O

Molecular Formula

C35H36F2N8O9S2

Molecular Weight

814.84

References & Citations

[1]Kovanda L L, et al. Isavuconazonium sulfate: a new agent for the treatment of invasive aspergillosis and invasive mucormycosis[J]. Expert review of clinical pharmacology, 2016, 9 (7) : 887-897.|[2]Shing B, et al. Evaluation of Amebicidal and Cysticidal Activities of Antifungal Drug Isavuconazonium Sulfate against Acanthamoeba T4 Strains. Pharmaceuticals (Basel) . 2021 Dec 11;14 (12) :1294.|[3]Slain D, et al. Isavuconazonium sulfate: a novel antifungal agent[J]. Current Fungal Infection Reports, 2015, 9: 302-313.|[4]Luo G, et al. Isavuconazole therapy protects immunosuppressed mice from mucormycosis[J]. Antimicrobial agents and chemotherapy, 2014, 58 (4) : 2450-2453.|[5]Scolarici MJ, et al. The Role of Isavuconazonium Sulphate for the Treatment of Blastomycosis: A Case Series and Antifungal Susceptibility. Open Forum Infect Dis. 2022 Apr 27;9 (7) :ofac220.