DMCM (hydrochloride) (Standard)
DMCM (hydrochloride) (Standard) is the analytical standard of DMCM (hydrochloride) . This product is intended for research and analytical applications. DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 ?receptors, respectively[1].
Product Specifications
CAS Number
1215833-62-7
UNSPSC
12352005
Target
GABA Receptor; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(C1=C(CC)C2=C(C=N1)NC3=C2C=C(OC)C(OC)=C3)OC.[H]Cl
Molecular Formula
C17H19ClN2O4
Molecular Weight
350.80
References & Citations
[1]Chambers MS, et al. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem. 2004 Nov 18;47 (24) :5829-32.|[2]Leppä E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA (A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48 (4) :469-78.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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