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MS049 (Standard)

MS049 (Standard) is the analytical standard of MS049 (HY-100360) . This product is intended for research and analytical applications. MS049, a chemical probe, is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells[1].

Product Specifications

CAS Number

[1502816-23-0]

Target

Histone Methyltransferase; Reference Standards

Related Pathways

Epigenetics; Others

Field of Research

Cancer

Smiles

CNCCN1CCC(OCC2=CC=CC=C2)CC1

Molecular Formula

C15H24N2O

Molecular Weight

248.36

References & Citations

[1]Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Sep 15.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Curated Selection

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