C12-Ceramide (Standard)
C12-Ceramide (Standard) is the analytical standard of C12-Ceramide. This product is intended for research and analytical applications. C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].
Product Specifications
CAS Number
[74713-60-3]
Product Name Alternative
N-Lauroyl-D-erythro-sphingosine (Standard) ; N-Laurylsphingosine (Standard)
UNSPSC
12352211
Target
Others; Reference Standards
Related Pathways
Others
Field of Research
Cancer; Metabolic Disease
Smiles
CCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
Molecular Formula
C30H59NO3
Molecular Weight
481.79
References & Citations
[1]He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314 (1) :116-20.|[2]Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8 (44) :76921-76934.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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