GNE-495 (Standard)
GNE-495 (Standard) is the analytical standard of GNE-495 (HY-100343) . This product is intended for research and analytical applications. GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.
Product Specifications
CAS Number
[1449277-10-4]
Target
MAP4K; Reference Standards
Related Pathways
MAPK/ERK Pathway; Others
Field of Research
Cancer
Smiles
O=C(C1=C2C=CC(C3=CC=CC(F)=C3)=NC2=C(N)N=C1)NC4CN(C(C5CC5)=O)C4
Molecular Formula
C22H20FN5O2
Molecular Weight
405.42
References & Citations
[1]Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6 (8) :913-8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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