GSK583 (Standard)
GSK583 (Standard) is the analytical standard of GSK583 (HY-100339) . This product is intended for research and analytical applications. GSK583 is a highly potent, orally active and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM. GSK583 inhibits both TNF-α and IL-6 production with an IC50 value of 200 nM.
Product Specifications
CAS Number
[1346547-00-9]
Target
Reference Standards; RIP kinase
Related Pathways
Apoptosis; Others
Field of Research
Endocrinology
Smiles
FC1=CC2=C(NN=C2NC3=CC=NC4=CC=C(S(=O)(C(C)(C)C)=O)C=C34)C=C1
Molecular Formula
C20H19FN4O2S
Molecular Weight
398.45
References & Citations
[1]Haile PA et al. The Identification and Pharmacological Characterization of 6- (tert-Butylsulfonyl) -N- (5-fluoro-1H-indazol-3-yl) quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem, 2016 May 26, 59 (10) :4867-80.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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