PF 477736 (Standard)
PF 477736 (Standard) is the analytical standard of PF 477736. This product is intended for research and analytical applications. PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows[2].
Product Specifications
CAS Number
952021-60-2
Target
Aurora Kinase; CDK; c-Fms; Checkpoint Kinase (Chk) ; FGFR; FLT3; Reference Standards; RET; Src; VEGFR
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C([C@@H](C1CCCCC1)N)NC2=CC3=C(C(C=NNC4=O)=C(N3)C5=CN(N=C5)C)C4=C2
Molecular Formula
C22H25N7O2
Molecular Weight
419.48
References & Citations
[1]Blasina A, et al. Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1. Mol Cancer Ther. 2008 Aug;7 (8) :2394-404|[2]Ashwell S, et, al. DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy. Clin Cancer Res. 2008 Jul 1; 14 (13) : 4032-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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