FR183998 free base (Standard)
FR183998 free base (Standard) is the analytical standard of FR183998 free base. This product is intended for research and analytical applications. FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.
Product Specifications
CAS Number
239440-20-1
Target
Na+/H+ Exchanger (NHE) ; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C(C1=CC(C2=C(Cl)SC(Cl)=C2)=CC(C(NCCN(C)C)=O)=C1)NC(N)=N
Molecular Formula
C17H19Cl2N5O2S
Molecular Weight
428.34
References & Citations
[1]Ohara F, et al. Preischemic and postischemic treatment with a new Na+/H+-exchange inhibitor, FR183998, shows cardioprotective effects in rats with cardiac ischemia and reperfusion. J Cardiovasc Pharmacol. 1999 Dec;34 (6) :848-56.|[2]Ishizaki M, et al. Protective effect of FR183998, a Na+/H+ exchanger inhibitor, and its inhibition of iNOS induction in hepatic ischemia-reperfusion injury in rats. Shock. 2008 Sep;30 (3) :311-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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