Nutlin-3a (Standard)
Nutlin-3a (Standard) is the analytical standard of Nutlin-3a. This product is intended for research and analytical applications. Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas[1][2].
Product Specifications
CAS Number
675576-98-4
Target
Apoptosis; Autophagy; E1/E2/E3 Enzyme; MDM-2/p53; Reference Standards
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=N[C@H]([C@H]1C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)N5CC(NCC5)=O
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.49
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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