Antihistamine-1 (Standard)
Antihistamine-1 (Standard) is the analytical standard of Antihistamine-1. This product is intended for research and analytical applications. Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
Product Specifications
CAS Number
1186430-60-3
Target
Cytochrome P450; Histamine Receptor; Potassium Channel; Reference Standards
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Neurological Disease; Endocrinology
Smiles
CC1=CN(C2CCN(C3=NC4=CC=CC=C4N3CC5=CC=C(F)C=C5)CC2)N=C1
Molecular Formula
C23H24FN5
Molecular Weight
389.47
References & Citations
[1]Lavrador-Erb K, et al. The discovery and structure-activity relationships of 2- (piperidin-3-yl) -1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia. Bioorg Med Chem Lett. 2010 May 1;20 (9) :2916-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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