Antihistamine-1 (Standard)

Antihistamine-1 (Standard) is the analytical standard of Antihistamine-1 (HY-100238) . This product is intended for research and analytical applications. Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.

Product Specifications

CAS Number

[1186430-60-3]

Target

Cytochrome P450; Histamine Receptor; Potassium Channel; Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease; Endocrinology

Smiles

CC1=CN(C2CCN(C3=NC4=CC=CC=C4N3CC5=CC=C(F)C=C5)CC2)N=C1

Molecular Formula

C23H24FN5

Molecular Weight

389.47

References & Citations

[1]Lavrador-Erb K, et al. The discovery and structure-activity relationships of 2- (piperidin-3-yl) -1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia. Bioorg Med Chem Lett. 2010 May 1;20 (9) :2916-9.