SZL P1-41 (Standard)
SZL P1-41 (Standard) is the analytical standard of SZL P1-41. This product is intended for research and analytical applications. SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities[1][2].
Product Specifications
CAS Number
222716-34-9
Target
Apoptosis; E1/E2/E3 Enzyme; Reference Standards
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C1C(C2=NC3=CC=CC=C3S2)=COC4=C(CN5CCCCC5)C(O)=C(CC)C=C14
Molecular Formula
C24H24N2O3S
Molecular Weight
420.52
References & Citations
[1]Chan CH et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 1;154 (3) :556-68.|[2]Chan CH, et al. Skp2: a dream target in the coming age of cancer therapy. Cell Cycle. 2014;13 (5) :679-80.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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