GSK591 (Standard)
GSK591 (Standard) is the analytical standard of GSK591. This product is intended for research and analytical applications. GSK591 (EPZ015866), a chemical probe, is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 4 nM[1].
Product Specifications
CAS Number
1616391-87-7
Target
Histone Methyltransferase; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
O=C(C1=CC(NC2CCC2)=NC=C1)NC[C@H](O)CN3CC4=C(C=CC=C4)CC3
Molecular Formula
C22H28N4O2
Molecular Weight
380.48
References & Citations
[1][1] Kenneth W. Duncan et al. Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med. Chem. Lett., 2016, 7 (2), pp 162-166.|[2]Chiang K, et al. PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression. Cell Rep. 2017 Dec 19;21 (12) :3498-3513.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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