IQ-1S (free acid) (Standard)
IQ-1S (free acid) (Standard) is the analytical standard of IQ-1S (free acid) (HY-100233) . This product is intended for research and analytical applications. IQ-1S free acid is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 2.3±0.41 μM. IQ-1S free acid has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.
Product Specifications
CAS Number
[23146-22-7]
Target
JNK; Reference Standards
Related Pathways
MAPK/ERK Pathway; Others
Field of Research
Cancer; Inflammation/Immunology
Smiles
O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2
Molecular Formula
C15H9N3O
Molecular Weight
247.25
References & Citations
[1]Schepetkin IA, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81 (6) :832-45.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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