ML-133
ML133 is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].
Product Specifications
CAS Number
185669-79-8
UNSPSC
12352005
Hazard Statement
H302-H315-H318-H335
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1
Molecular Formula
C19H19NO
Molecular Weight
277.36
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Wang HR, et al. Selective inhibition of the K (ir) 2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6 (8) :845-56.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
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