SKF89976A (hydrochloride) (Standard)
SKF89976A (hydrochloride) (Standard) is the analytical standard of SKF89976A (hydrochloride). This product is intended for research and analytical applications. SKF89976A hydrochloride is a selective GABA transporter (GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.
Product Specifications
CAS Number
85375-15-1
Target
GABA Receptor; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(C1CN(CC/C=C(C2=CC=CC=C2)/C3=CC=CC=C3)CCC1)O.[H]Cl
Molecular Formula
C22H26ClNO2
Molecular Weight
371.90
References & Citations
[1]Jinzenji A, et al. Antiallodynic action of 1- (3- (9H-Carbazol-9-yl) -1-propyl) -4- (2-methyoxyphenyl) -4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor. J Pharmacol Sci. 2014;125 (2) :217-26.|[2]Kreitzer MA, et al. Glutamate modulation of GABA transport in retinal horizontal cells of the skate. J Physiol. 2003 Feb 1;546 (Pt 3) :717-31.|[3]Barakat L, et al. GAT-1 and reversible GABA transport in Bergmann glia in slices. J Neurophysiol. 2002 Sep;88 (3) :1407-19.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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