GSK6853 (Standard)
GSK6853 (Standard) is the analytical standard of GSK6853 (HY-100220) . This product is intended for research and analytical applications. GSK6853, a chemical probe, is a potent and selective inhibitor of the BRPF1 bromodomain. GSK6853 shows excellent BRPF1 potency (pKd = 9.5) and greater than 1600-fold selectivity over all other bromodomains[1].
Product Specifications
CAS Number
[1910124-24-1]
Target
Epigenetic Reader Domain; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
C[C@@H]1CNCCN1C2=C(NC(C3=CC=CC=C3OC)=O)C=C(C(N4C)=C2)N(C)C4=O
Molecular Formula
C22H27N5O3
Molecular Weight
409.48
References & Citations
[1]Bamborough P et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7 (6) :552-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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KCNQ1, NT (KCNQ1, KCNA8, KCNA9, KVLQT1, Potassium voltage-gated channel subfamily KQT member 1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1) (MaxLight 490)
KCNQ1, NT (KCNQ1, KCNA8, KCNA9, KVLQT1, Potassium voltage-gated channel subfamily KQT member 1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1) (MaxLight 490)
