(1R,3R) -RSL3 (Standard)
(1R,3R) -RSL3 (Standard) is the analytical standard of (1R,3R) -RSL3. This product is intended for research and analytical applications. (1R,3R) -RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R) -RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1].
Product Specifications
CAS Number
1219810-15-7
Target
Drug Isomer; Ferroptosis; Reference Standards
Related Pathways
Apoptosis; Others
Field of Research
Cancer
Smiles
O=C([C@H]1CC2=C([C@@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC
Molecular Formula
C23H21ClN2O5
Molecular Weight
440.88
References & Citations
[1]Shin D, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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