SPDP (Standard)
SPDP (Standard) is the analytical standard of SPDP. This product is intended for research and analytical applications. SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs)[2].
Product Specifications
CAS Number
68181-17-9
Target
ADC Linker; Reference Standards
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Field of Research
Cancer
Smiles
O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
Molecular Formula
C12H12N2O4S2
Molecular Weight
312.37
References & Citations
[1]Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104 (11) :4612-7.|[2]Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184 (12) :6695-708.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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