SPDP (Standard)

SPDP (Standard) is the analytical standard of SPDP (HY-100216) . This product is intended for research and analytical applications. SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) [1][2].

Product Specifications

CAS Number

[68181-17-9]

Target

ADC Linker; Reference Standards

Related Pathways

Antibody-drug Conjugate/ADC Related; Others

Field of Research

Cancer

Smiles

O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2

Molecular Formula

C12H12N2O4S2

Molecular Weight

312.37

References & Citations

[1]Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104 (11) :4612-7.|[2]Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184 (12) :6695-708.