EAI001 (Standard)
EAI001 (Standard) is the analytical standard of EAI001. This product is intended for research and analytical applications. EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer[1][2].
Product Specifications
CAS Number
892772-75-7
Target
EGFR; Reference Standards
Related Pathways
JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C(C1=CC=CC=C1)N2C(C(C=CC=C3)=C3C2)=O)NC4=NC=CS4
Molecular Formula
C19H15N3O2S
Molecular Weight
349.41
References & Citations
[1]Maity S, et, al. Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance. Pharmacol Rep. 2020 Aug;72 (4) :799-813.|[2]Tinivella A, et, al. Investigating the selectivity of allosteric inhibitors for mutant t790m egfr over wild type using molecular dynamics and binding free energy calculations. 2018 Dec 4;3 (12) :16556-62.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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