TAPI-2 (Standard)
TAPI-2 (Standard) is the analytical standard of TAPI-2. This product is intended for research and analytical applications. TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP[1]. TAPI-2 blocks the entry of infectious SARS-CoV[2].
Product Specifications
CAS Number
187034-31-7
Target
MMP; Reference Standards; SARS-CoV
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
CC(C)(C)[C@@H](C(N[C@H](C(NCCN)=O)C)=O)NC(C(CC(NO)=O)CC(C)C)=O
Molecular Formula
C19H37N5O5
Molecular Weight
415.53
References & Citations
[1]Kruse MN, et al. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochem J. 2004 Mar 1;378 (Pt 2) :383-9.|[2]Wang R, et al. A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. Stem Cells Transl Med. 2016 Mar;5 (3) :331-8.|[3]Shiori Haga, et al. TACE Antagonists Blocking ACE2 Shedding Caused by the Spike Protein of SARS-CoV Are Candidate Antiviral Compounds. Antiviral Res. 2010 Mar;85 (3) :551-5.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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