A-196 (Standard)
A-196 (Standard) is the analytical standard of A-196 (HY-100201) . This product is intended for research and analytical applications. A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity[1].
Product Specifications
CAS Number
[1982372-88-2]
Target
Histone Methyltransferase; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1
Molecular Formula
C18H16Cl2N4
Molecular Weight
359.25
References & Citations
[1]Bromberg KD, et al. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol. 2017 Mar;13 (3) :317-324.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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