SMER28 (Standard)
SMER28 (Standard) is the analytical standard of SMER28 (HY-100200) . This product is intended for research and analytical applications. SMER28 is a positive regulator of autophagy acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.
Product Specifications
CAS Number
[307538-42-7]
Target
Autophagy; Reference Standards
Related Pathways
Autophagy; Others
Field of Research
Cancer
Smiles
C=CCNC1=C2C=C(Br)C=CC2=NC=N1
Molecular Formula
C11H10BrN3
Molecular Weight
264.12
References & Citations
[1]Renna M et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem. 2010 Apr 9;285 (15) :11061-7.|[2]Shen D et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60 (3) :173-85.|[3]Tian Y et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25 (6) :1934-42.|[4]Nekova TS, et al. Small molecule enhancers of rapamycin induce apoptosis in myeloma cells via GSK3A/Bpreferentially within a protective bone marrow microenvironment. Br J Haematol. 2014 Oct;167 (2) :272-4.|[5]Koukourakis MI, et al. SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone marrow and liver against radiotherapy. Invest New Drugs. 2018 Oct;36 (5) :773-781.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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