GSK2239633A (Standard)
GSK2239633A (Standard) is the analytical standard of GSK2239633A. This product is intended for research and analytical applications. GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96.
Product Specifications
CAS Number
1240516-71-5
Target
CCR; Reference Standards
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology; Endocrinology
Smiles
CC(C)(O)C(NCC1=CC=CC(CN2N=C(NS(=O)(C3=CC=C(Cl)S3)=O)C4=C2C=CC=C4OC)=C1)=O
Molecular Formula
C24H25ClN4O5S2
Molecular Weight
549.06
References & Citations
[1]Cahn A, et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study. BMC Pharmacol Toxicol. 2013 Feb 28;14:14.|[2]Slack RJ, et al. Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor. Pharmacol Res Perspect. 2013 Dec;1 (2) :e00019.|[3]Miah AH, et al. Identification of pyrazolopyrimidine arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists. Bioorg Med Chem. 2017 Oct 15;25 (20) :5327-5340.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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