BACE1-IN-1 (Standard)
BACE1-IN-1 (Standard) is the analytical standard of BACE1-IN-1. This product is intended for research and analytical applications. BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
Product Specifications
CAS Number
1310347-50-2
Target
Beta-secretase; Reference Standards
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(C1=NC=C(C#N)C=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)OCC3(F)F)=C2
Molecular Formula
C18H14F3N5O2
Molecular Weight
389.33
References & Citations
[1]Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56 (10) :3980-95.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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