BACE1-IN-1 (Standard)

BACE1-IN-1 (Standard) is the analytical standard of BACE1-IN-1 (HY-100182) . This product is intended for research and analytical applications. BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.

Product Specifications

CAS Number

[1310347-50-2]

Target

Beta-secretase; Reference Standards

Related Pathways

Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

O=C(C1=NC=C(C#N)C=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)OCC3(F)F)=C2

Molecular Formula

C18H14F3N5O2

Molecular Weight

389.33

References & Citations

[1]Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56 (10) :3980-95.