PF-4878691 (Standard)

PF-4878691 (Standard) is the analytical standard of PF-4878691. This product is intended for research and analytical applications. PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer[1][2].

Product Specifications

CAS Number

[532959-63-0]

Product Name Alternative

3M-852A (Standard)

UNSPSC

12352005

Target

Apoptosis; HCV; Interleukin Related; Reference Standards; TNF Receptor; Toll-like Receptor (TLR)

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Smiles

CS(=O)(NCCCCN1C(CC)=NC2=C1C3=CC=CC=C3N=C2N)=O

Molecular Formula

C17H23N5O2S

Molecular Weight

361.46

References & Citations

[1]Fidock MD, et al. The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691) . Clin Pharmacol Ther. 2011 Jun;89 (6) :821-9.|[2]Horscroft NJ, et al. Antiviral applications of Toll-like receptor agonists. J Antimicrob Chemother. 2012 Apr;67 (4) :789-801.|[3]Birmachu W, et al. Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists [J]. BMC immunology, 2007, 8: 1-19.