PAP-1 (Standard)

PAP-1 (Standard) is the analytical standard of PAP-1. This product is intended for research and analytical applications. PAP-1 (5- (4-Phenoxybutoxy) psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM) . PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects[1][2].

Product Specifications

CAS Number

[870653-45-5]

Product Name Alternative

5- (4-Phenoxybutoxy) psoralen (Standard)

UNSPSC

12352005

Target

Potassium Channel; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Inflammation/Immunology

Smiles

O=C1C=CC(C(O1)=CC2=C3C=CO2)=C3OCCCCOC4=CC=CC=C4

Molecular Formula

C21H18O5

Molecular Weight

350.36

References & Citations

[1]Schmitz A, et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov;68 (5) :1254-70.|[2]Pereira LE, et al. Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5- (4-phenoxybutoxy) psoralen in rhesus macaques. Exp Biol Med (Maywood) . 2007 Nov;232 (10) :1338-54.