DM1-SMe (Standard)
DM1-SMe (Standard) is the analytical standard of DM1-SMe. This product is intended for research and analytical applications. DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is the microtubule inhibitor and can be used as the ADC cytotoxin[1].
Product Specifications
CAS Number
138148-68-2
Target
ADC Payload; Microtubule/Tubulin; Reference Standards
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton; Others
Field of Research
Cancer
Smiles
C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCSSC)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1
Molecular Formula
C36H50ClN3O10S2
Molecular Weight
784.38
References & Citations
[1]Wood AC, et al. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013;60 (11) :1860-1867. |[2]Chari RV. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res. 2008;41 (1) :98-107.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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