(Rac) -SCH 563705 (Standard)
(Rac) -SCH 563705 (Standard) is the analytical standard of (Rac) -SCH 563705. This product is intended for research and analytical applications. (Rac) -SCH 563705 is a racemic mixture of SCH 563705 (HY-10011). SCH 563705 (compound 16) is a potent and orally active CXCR2 and CXCR1 antagonist with IC50 values of 1.3 nM and 7.3 nM and Ki values of 1 nM and 3 nM, respectively[1][2].
Product Specifications
CAS Number
2701435-64-3
Target
CXCR; Reference Standards
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Others
Field of Research
Endocrinology; Inflammation/Immunology
Smiles
O=C(C(NC1=CC=CC(C(N(C)C)=O)=C1O)=C2NC(CC)C3=CC(C(C)C)=CO3)C2=O
Molecular Formula
C23H27N3O5
Molecular Weight
425.48
References & Citations
[1]Min S H, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis[J]. Biochemical and biophysical research communications, 2010, 391 (1) : 1080-1086.|[2]Chao J, et al. C (4) -alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists[J]. Bioorganic & medicinal chemistry letters, 2007, 17 (13) : 3778-3783.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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