Buloxibutid (Standard)
Buloxibutid (Standard) is the analytical standard of Buloxibutid. This product is intended for research and analytical applications. Buloxibutid (AT2 receptor agonist C21) is a agentlike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 μM for the AT2 receptor and AT1 receptor, respectively[1].
Product Specifications
CAS Number
477775-14-7
Target
Angiotensin Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Cardiovascular Disease; Endocrinology
Smiles
O=C(OCCCC)NS(=O)(C1=C(C2=CC=C(CN3C=CN=C3)C=C2)C=C(CC(C)C)S1)=O
Molecular Formula
C23H29N3O4S2
Molecular Weight
475.62
References & Citations
[1]Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004 Nov 18;47 (24) :5995-6008.|[2]Schwengel K, Namsolleck P, Lucht K, et al. Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice. J Mol Med (Berl) . 2016;94 (8) :957-966. |[3]Fatima N, Patel S, Hussain T. Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10. Front Pharmacol. 2021;12:600163.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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