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KNK437 (Standard)

KNK437 (Standard) is the analytical standard of KNK437. This product is intended for research and analytical applications. KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.

Product Specifications

CAS Number

218924-25-5

Target

HSP; Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=CN1C(/C(CC1)=C/C2=CC=C(OCO3)C3=C2)=O

Molecular Formula

C13H11NO4

Molecular Weight

245.23

References & Citations

[1]Yokota S, et al. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells. Cancer Res. 2000 Jun 1;60 (11) :2942-8.|[2]Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7 (1) :215-9.|[3]Matsuda K, et al. Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells. Int J Hyperthermia. 2006 Dec;22 (8) :729-35.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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