KNK437 (Standard)
KNK437 (Standard) is the analytical standard of KNK437 (HY-100110) . This product is intended for research and analytical applications. KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.
Product Specifications
CAS Number
[218924-25-5]
Target
HSP; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=CN1C(/C(CC1)=C/C2=CC=C(OCO3)C3=C2)=O
Molecular Formula
C13H11NO4
Molecular Weight
245.23
References & Citations
[1]Yokota S, et al. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells. Cancer Res. 2000 Jun 1;60 (11) :2942-8.|[2]Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7 (1) :215-9.|[3]Matsuda K, et al. Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells. Int J Hyperthermia. 2006 Dec;22 (8) :729-35.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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