NT157 (Standard)
NT157 (Standard) is the analytical standard of NT157. This product is intended for research and analytical applications. NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway[1][2].
Product Specifications
CAS Number
1384426-12-3
Target
Insulin Receptor; Reference Standards; STAT
Related Pathways
JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer; Endocrinology
Smiles
S=C(NCC1=CC(O)=C(O)C(O)=C1)/C=C/C2=CC(O)=C(O)C(Br)=C2
Molecular Formula
C16H14BrNO5S
Molecular Weight
412.26
References & Citations
[1]Downregulated the Tyr-phosphorylation of IRS-1 in the MG-63 and U-2OS cells.|[2]Flashner-Abramson E, et al. Targeting melanoma with NT157 by blocking Stat3 and IGF1R signaling. Oncogene. 2016 May 19;35 (20) :2675-80.|[3]Ibuki N, et al. The tyrphostin NT157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. Mol Cancer Ther. 2014 Dec;13 (12) :2827-39.|[4]Ishii H, et al. miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity. Nat Commun. 2018 Jul 4;9 (1) :2611.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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