MK-4101 (Standard)
MK-4101 (Standard) is the analytical standard of MK-4101. This product is intended for research and analytical applications. MK-4101 is a Smoothened (SMO) antagonist (IC50 of 1.1 μM for 293 cells) and also a potent inhibitor of the hedgehog pathway (IC50 of 1.5 μM for mouse cells; IC50 of 1 μM for KYSE180 oesophageal cancer cells). MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis[1].
Product Specifications
CAS Number
935273-79-3
Target
Apoptosis; Hedgehog; Reference Standards; Smo
Related Pathways
Apoptosis; Others; Stem Cell/Wnt
Field of Research
Cancer
Smiles
FC(C1=CC=CC=C1C2=NN=C(C34CCC(C5=NOC(C6CC(F)(F)C6)=N5)(CC4)CC3)N2C)(F)F
Molecular Formula
C24H24F5N5O
Molecular Weight
493.47
References & Citations
[1]Filocamo G et al. MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.
 Mol Cancer Ther. 2016 Jun;15 (6) :1177-89.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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